Composition
Tab: Abemaciclib 150 mg
Indications & Dosage
Breast cancer (specialist use only): Adult: 150 mg twice daily, for dose adjustments, treatment interruption, or discontinuation due to side-effects consult product literature.
Precautions
Severe hepatic and renal impairment. Monitor full blood count, and alanine and aspartate aminotransferases before starting treatment, every 2 weeks for the first 2 months, monthly for the following 2 months thereafter. Use effective contraception in women of childbearing potential during treatment and for at least 3 weeks after completing treatment.
Interactions
CYP3A4 inhibitor
Pregnancy
Avoid unless essential
Lactation
Contraindicated. Discontinue breast feeding
Side Effects
Alopecia, anaemia, appetite decreased, decreased leucocytes, diarrhoea, dizziness, dyspepsia, embolism and thrombosis, excessive tearing, fatigue, fever, headache, increased risk of infection, muscle weakness, nail disorder, nausea, neutropenia, respiratory disorders, skin reactions, stomatitis, taste altered, thrombocytopenia, vomiting. Rare: Neutropenic sepsis