ACEMOX
ACETAZOLAMIDE · by VEGA
Composition
Tab 125 mg/250 mg: Acetazolamide 125 mg/250 mg.
Indications & Dosage
Reduction of intra-ocular pressure in open-angle glaucoma or secondary glaucoma or peri-operatively in angle-closure glaucoma: Adult: 0.25-1 g daily in divided doses, intramuscular injection preferably avoided because of alkalinity. Children: 20-40 mg/kg/24 hr divided every 6 hr, not to exceed 1 gm/day. Oedema: Adults & Children: 250-375 mg once daily. Epilepsy: Adult: 0.25-1 g daily in divided doses, intramuscular injection preferably avoided because of alkalinity.
Contraindications
Adrenocortical insufficiency, hyperchloraemic acidosis, hypokalaemia, hyponatraemia, long-term administration in chronic angle-closure glaucoma. Avoid in hepatic and renal impairment
Precautions
Diabetes mellitus, gout, elderly, impaired alveolar ventilation; risk of acidosis, not recommended for long-term use, pulmonary obstruction; risk of acidosis, renal calculi. Monitor fluid, electrolytes and blood, potassium supplements may be required.
Interactions
Folic acid antagonists, hypoglycaemics, oral anticoagulants.
Pregnancy
Avoid
Lactation
Caution advised
Side Effects
Headache, drowsiness, ataxia, depression, diarrhoea, dizziness, excitement, fatigue, irritability, loss of appetite, nausea, reduced libido, taste disturbance, vomiting polyuria, paraesthesia, blood dyscrasias, excitement, flushing, thirst, rash.