ADMIT
SITAGLIPTIN · by SHAIGAN
Composition
Tab 25 mg/50 mg/100 mg: Sitagliptin 25 mg/50 mg/100 mg (as phosphate monohydrate).
Indications & Dosage
Type 2 diabetes mellitus as monotherapy or in combination with metformin or a sulfonylurea, or pioglitazone (duel therapy), and in combination with both metformin and a sulfonylurea (triple therapy) to achieve adequate glycaemic control: Adult: 100 mg once daily Type 2 diabetes mellitus in combination with both metformin and pioglitazone, or in combination with insulin (withor without metformin) when insulin alone fails to provide adequate glycaemic control: Adult: 100 mg once daily Dose of concomitant sulfonylurea or insulin may need to be reduced. Children: Not recommended.
Contraindications
Ketoacidosis, severe renal impairment.
Precautions
Elderly, renal impairment reduce dose to 50 mg once daily if eGFR 30-50 ml/minute/1.73m2, reduce dose to 25mgonce daily if eGFR less than 30 ml/minute/1.73m2.
Interactions
Digoxin
Pregnancy
Contraindicated in pregnancy.
Lactation
Not recommended.
Side Effects
GI disturbances, nasopharyngitis, pain, peripheral oedema, upper respiratory tract infection, anorexia, dizziness, drowsiness, dry mouth, headache, hypoglycaemia, cutaneous vasculitis, pancreatitis (discontinue) rash, Stevens-Johnson syndrome, osteoarthritis.