ADS
ATOMOXETINE · by WILSHIRE
Composition
Cap/Tab 8mg/10 mg/16mg/25 mg/40 mg/60 mg: Atomoxetine HCI equiv to Atomoxetine 8mg/10 mg/16 mg/25 'mg/40 mg/60 mg
Indications & Dosage
Treatment of attention deficit hyperactivity disorder (ADHD): Adults: Initially 40 mg/day given every morning or evenly divided doses in morning & late afternoon/early evening. Increase after minimum of 3 day to target dose of about 80 mg/day. After 2-4 weeks, may increase to max of 100 mg/day. Children above6 yr: (body-weight under 70 kg): Initially 500 mcg/kg daily for 7 days, increased according response; usual maintenance dose 1.2 mg/kg daily, but may be increased to 1.8 mg/kg daily, max 100 mg daily; Doses above 100 mg daily is not recommended foruse. Total daily dose may be given either as a single dose in the morning or in 2 divided doses with last dose no later than early evening.
Contraindications
: Use of MAOIs within 14 days, narrow-angle glaucoma.
Precautions
Congenital, acquired or family history of QT prolongation. Hepatic or renal insufficiency, hypertension, tachycardia, cardiovascular or cerebrovascular disease, history of seizures; discontinue if occur. Monitor pulse and BP periodically. Monitor growth, development, cognition and sexual maturation during long term treatment. Monitor for suicidal ideation, hostility and emotional liability.
Interactions
MAOIs, fluoxetine, quinidine, terbinafine, other CYP2D6 inhibitors, salbutamol, other beta2-agonists, pressor agents, antidepressants, decongestants, drugs that prolong the QT interval, cause electrolyte imbalance or reduce seizure threshold.
Pregnancy
Avoid unless benefits out-weigh risk
Lactation
Caution advised
Side Effects
Agitation, abdominal pain, blood disorder, sleep disorder, decreased appetite, weight loss, anorexia, early waking, somnolence, dizziness, irritability, mood swings, mydriasis, GI disturbance, skin reactions, Discontinue if signs of liver injury.