ALIUM
CHLORDIAZEPOXIDE · by AMROS
Composition
Tab 5 mg/10 mg: Chlordiazepoxide 5 mg/10 mg.
Indications & Dosage
Short-term use in anxiety: Adult: 10 mg 3 times a day, increased if necessary to 60-100 mg daily in divided doses, for debilitated patients, use elderly dose. Elderly: 5 mg 3 times a day, increased if necessary to30-50 mg daily in divided doses. Treatment of alcohol withdrawal: Adult: moderate dependence: 10-30 mg 4 times a day, dose to be gradually reduced over 5-7 days; severe dependence: 10-50 mg 4 times a day and 10-40 mg as required for the first 2 days, dose to be gradually reduced over 7-10 days; max. 250 mg per day.
Contraindications
Respiratory depression, chronic psychosis, hyperkinesis, obsessional states, phobic states, acute pulmonary insufficiency. Not recommended for use alone to treat depression (or anxiety associated with depression)
Precautions
Muscle weakness, organic brain changes, personality disorder (dependent, avoidant, obsessive-compulsive) may increase risk of dependence, chronic pulmonary insufficiency, severe renal or hepatic impairment, elderly. Avoid long-term use. Withdraw gradually.
Interactions
Alcohol, CNS depressants, anticonvulsants, CYP3A4 inhibitors or inducers (e.g, cimetidine, rifampicin).
Pregnancy
Contraindicated
Lactation
Contraindicated
Side Effects
Amnesia, ataxia, headache, confusion, dependence, drowsiness, lightheadedness, muscle weakness, paradoxical increase in aggression, changes in libido, dizziness, dysarthria, GI disturbances, gynaecomastia, hypotension, incontinence, salivation changes, slurred speech, tremor, urinary retention, vertigo, visual disturbances. Rare: Apnoea, blood disorders, respiratory depression, skin reactions