Composition
Inj: Per ml: Flumazenil 1000 mcg; 10 ml (1 mg), 5 ml (0.5 mg) amp
Indications & Dosage
Reversal of sedative effects of benzodiazepines in anaesthesia and clinical procedures: BY IV INJ: Adult: 200 mcg, dose to be administered over15 seconds, then 100 mcg every 1 minute if required; usual dose 300-600 mcg; max.1 mg per course Children: 10 mcg/kg (max 200 mcg), repeated at 1-minute intervals if required, max total dose of 50 mcg/kg (1 mg). Reversal of sedative effects of benzodiazepines in intensive care: BY IV INJ: Adult: 300 mcg, dose to be administered over 15 seconds, then 100 mcg every 1 minute if required; max. 2 mg per course. Children: 10 mcg/kg (max 200 mcg), repeated at 1-minute intervals if required, max total dose of 50 mcg/kg (2 mg). Reversal of sedative effects of benzodiazepines in intensive care (if drowsiness recurs after injection): BY IV INF: Adult: 100-400 mcg/hour, adjusted according to response, alternatively (by IV injection) 300 mcg, adjusted according to response. Children: 2-10mcg/kg/hr, adjusted according to response, max 400 mcg/hr.
Administration
Administered IV over 15 to 30 seconds. To minimize pain at the injection site, Flumazenil should be ad-ministered through a freely running IV infusion line into a large vein. Extravasation should be avoided.
Compatibility
Dextrose 5%, NS, LR.
Stability
Stored at controlled room temperature.
Contraindications
Life-threatening condition (e.g. raised intracranial pressure, status epileptic us) controlled by benzodiazepines
Precautions
Head injury, avoid rapid injection following major surgery or in high-risk or anxious patients, benzodiazepine dependence (may precipitate withdrawal symptoms), elderly, ensure neuromuscular blockade cleared before administering, history of panic disorders, prolonged benzodiazepine therapy for epilepsy, short-acting (repeat doses may be necessary)
Pregnancy
Caution advised
Lactation
Caution advised
Side Effects
Nausea, vomiting, anxiety, fear, palpitation, agitation, chills, convulsions, dizziness, flushing, if wakening too rapid, transient increase in blood pressure and heart-rate in intensive care patients; very rarely convulsions (particularly in epileptics).