Composition
Inj: Per 1 ml amp: Prochlorperazine mesilate 12. 5 mg.Tab 3 mg/5 mg: Prochlorperazine maleate 3 mg/5 mg.
Indications & Dosage
Nausea and vomiting, acute attack: ORAL: Adult: Initially 20 mg, then 10 mg after 2 hours BY DEEP IM INJ: Adult: 12.5 mg as required, followed by an oral dose after 6 hours,if necessary. Nausea and vomiting, prevention and treatment: ORAL: Adult: 5-10 mg 2-3 times a day. Children 1-11 years (body-weight 10 kg and above): 250 mcg/kg 2-3 times a day; 12-17 years: 5-10 mg up to 3 times a day ifrequired. BY DEEP IM INJ: Adult: 12.5 mg as required, followed by an oral dose after 6 hours, if necessary. Children 2-4 years: 1.25-2.5 mg up to 3 times a day if required; 5-11 years: 5-6.25 mg up to 3 times a day if required; 12-17 years: 12.5 mg up to 3 times a day if required Labyrinthine disorders: ORAL: Adult: 5 mg 3 times a day, increased if necessary to 30 mg daily in divided doses, increased gradually, then reduced to 5-10 mg daily, dose is reduced after several wks Nausea and vomiting in previously diagnosed migraine: ORAL: Adult & Children 12 yrs: 3-6 mg twice daily. Schizophrenia and other psychoses, Mania: ORAL: Adult: 12.5 mg twice daily for 7 days, dose to be adjusted at intervals of 4-7 days according to response; usual dose 75-100 mg daily. BY DEEP IM INJ: Adult: 12.5-25 mg 2-3 times a day. Short-term adjunctive management of severe anxiety: ORAL: Adult: 15-20 mg daily in divided doses; max. 40 mg per day. Doses are expressed as prochlorperazine maleate or mesilate; 1mg prochlorperazine maleate:1 mg prochlorperazine mesilate.
Administration
IV: Administer IV doses as 30 min infusion or by slow (5-10 min) IV push. IV infusion must be diluted in 50-100 ml NS or D5W. IV injection may be given undiluted. IM: Inject IM form slowly, deep into upper outer quadrant of buttocks. Keep patient supine for 30 mins after injection to minimize hypotensive effects. Rotate IM Inj sites to prevent irritation and sterile abscesses.
Compatibility
Stable in NS, D5W, D1 OW, LR, 1/2NS, DSNS, DSLR.
Stability
Intact vials or ampoules are stable at room temperature. Protect from light.
Contraindications
Children under 10 kg body weight, CNS depression, comatose states, phaeochromocytoma, bone marrow depression, liver impairment.
Precautions
Undiagnosed and prolonged vomiting, elderly, hypotension, cardiovascular disease.
Interactions
CNS depressants, alcohol, analgesics, antihypertensives, antidepressants, anticonvulsants, antidiabetics.
Pregnancy
Caution advised
Lactation
Caution advised
Side Effects
Impaired judgment and dexterity, CNS disturbances, acute dys tonic reactions such as facial and skeletal muscle spasms and oculogyric crises, anticholinergic effects, ECG and endocrine changes, allergic effects and extra-pyramidal symptoms occur rarely at low dosage.