Composition
S Inj: Per ml: Iron as iron sucrose 20 mg; 5 ml(100 mg) amp.
Indications & Dosage
Iron deficiency anaemia: A test dose of 1 ml. to 2.5 ml in adults, 1 ml in children above 14 kg body wt and half the daily dose (1.5 mg/kg) in children less than 14 kg wt should be given by chosen method of administration. Facilities for cardiopulmonary resuscitation must be available. If no adverse reaction observed in at least 15 min, the remaining portion of the dose is given. BY IV DRIP INF: Adults & Elderly: 10 ml By IV INF, if required the single dose may be increased to 0.35 ml iron sucrose/kg body wt (7 mg iron/kg body wt) not exceeding 25 ml diluted in 500 ml 0.9% NaCI infused over at least 3.5 hr, once a wk. Children: 0.35 ml/kg body wt (7 mg/iron/kg body wt) diluted in 0.9% NaCI and infused over at least 3.5 hr. once a wk. BY SLOW INJECTION (or directly into the venous limb of the dialyzer but not by IM inj): Adults & Elderly: Two or three times a wk. A single dose of 5-10 ml (100-200 mg) injected in at least 10 min.
Administration
Iron sucrose must only be administered IV either by slow injection or by infusion. For IV infusion, give intermittently in Sodium chloride 0.9%,dilute 100mg in up to 100ml infusion fluid; give 25mgover 15 minutes initially, then give at a rate not exceeding3.33 mg/minute. Hemodialysis dependent-chronic kidney disease: Dose may be administered undiluted by slow IV injector over 2-5 min, or it may be diluted in a maximum of 100 ml NS and administered by IV infusion over a period of anent 15 min. Non-dialysis dependent-chronic kidney disease: Slowly administer IV injection undiluted over 2-5 min. Peritoneal dialysis dependent-chronic kidney disease: Infuse over 2.5 hours 14 days later. The iron sucrose dose should be diluted in a maximum of 250 ml of NS.
Stability
Store in original carton at 25oC (77o F). Excursions are permitted to 15o-30oC (59o-86oF). Do not freeze. It contains no preservatives.
Contraindications
Anaphylaxis, asthma, eczema, history of allergic disorders, Anaemia not caused by iron deficiency. Iron overload or disturbances in iron utilization, known hypersensitivity to iron mono- or disaccharide complexes, serious liver or kidney damage.
Precautions
History of allergy or chronic infection.
Side Effects
Cardiac arrhythmias, abdominal pain, bronchospasm, chest pain, diarrhoea, dizziness, dyspnea, fever, flushing, headache, hypotension, injection-site reactions, myalgia, nausea, vomiting, palpitation, pruritus, tachycardia, skin rash.