Composition
Tab: Anastrozole1 mg.
Indications & Dosage
Adjuvant treatment of oestrogen-receptor-positive early invasive breast cancer in postmenopausal women or following 2-3 years of tamoxifen therapy or advanced breast cancer in postmenopausal women which is oestrogen-receptor positive or responsive to tamoxifen: Adult: 1 mg daily. Children: Not recommended.
Contraindications
Pre-menopausal women, moderate to severe hepatic impairment, severe renal impairment; avoid if creatinine clearance less than 20 ml/minute,
Precautions
Laboratory test for menopause if doubt. Susceptibility to osteoporosis; assess bone mineral density before treatment and at regular intervals.
Interactions
Oestrogens.
Pregnancy
Positive evidence of risk: Avoid
Lactation
Avoid. Discontinue breast-feeding.
Side Effects
Allergic reactions, anaphylaxis, angioedema, anorexia, arthralgia, arthritis, asthenia, bone fractures, bone pain, cutaneous vasculitis, diarrhoea, drowsiness, hair thinning, headache, hot flushes, nausea, rash, slight increases in total cholesterol levels, Stevens-Johnson syndrome, vaginal bleeding, vaginal dryness, vomiting.