ATCO DAP
DAPAGLIFLOZIN · by GENIX
Composition
Tab 5mg/10 mg: Dapagliflozin 5mg/10 mg
Indications & Dosage
Type 2 diabetes mellitus as monotherapy (if metformin inappropriate), Type 2 diabetes mellitus in combination with insulin or other antidiabetic drugs (if existing treatment fails to achieve adequate glycaemic control): Adult 18-74 yrs: 10 mg once daily Adult 75 yrs and over: Initiation not recommended
Contraindications
Diabetic ketoacidosis, elderly over 80 yrs age, moderate to severe renal failure, volume depletion
Precautions
Cardiovascular disease, heart failure, elderly; risk of hypotension, electrolyte disturbances, hypotension, raised haematocrit, pyelonephritis, urosepsis,glycosuria. Correct hypovolaemia before starting treatment to avoid risk of volume depletion. Consider interrupting treatment if volume depletion occurs. In severe hepatic impairment, initial dose should be 5 mg daily then increased according to response. In renal impairment avoid if eGFR less than 60 ml/minute/1.73m2 (ineffective).
Interactions
Diuretics, antihypertensive, ACE inhibitors, angiotensin II antagonist, DPP4 inhibitors, incretin mimetics
Pregnancy
Contraindicated
Lactation
Contraindicated
Side Effects
Genital infection, hypoglycaemia (in combination with insulin or sulfonylurea), polyuria, pruritus, urinary tract infection, dysuria, haematocrit, volume depletion (rare)