AZACTAM
AZTREONAM · by GSK
Composition
Inj 500 mg/ 1gm: Aztreonam 500 mg/1 gm, powder for injection
Indications & Dosage
Gram-negative infections including Pseudomonas aeruginosa, Haemophilus influenzae, and Neisseria meningitidis: BY DEEP IM INJ, OR BY IV INF, OR BY IV INJ: Adult: 1 gm every 8 hours, alternatively 2 g every 12 hours, single doses over 1 g IV route only. Severe gram-negative infections including Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria meningitidis, and lung infections in cystic fibrosis: BY IV INF, OR BY IV INJ: Adult: 2 g every 6-8 hours. Gonorrhoea, Cystitis: BY INTRAMUSCULAR INJECTION: Adult: 1 g for 1 single dose. Urinary-tract infections: BY DEEP IM INJ, OR BY IV INF, OR BY IV INJ: Adult: 0.5-1 g every 8-12 hours.
Administration
For IV injection, dissolve in water for injections, give over 3-5 minutes. For IV infusion, give intermittently in Glucose 5% or Sodium chloride 0.9%. Dissolve initially in water for injections (1 g per 3 ml) then dilute to a concentration of less than 20 mg/ml; to be given over 20-60 minutes
Contraindications
Hypersensitivity to other beta-lactams.
Precautions
Chronic hepatic impairment with cirrhosis, renal impairment, electrolyte disturbances, may aggravate myasthenia gravis, predisposition to QT interval prolongation, cardiac desease, diabetes, elderly patients.
Pregnancy
Avoid unless essential
Lactation
Caution advised
Side Effects
Abdominal discomfort, dyspnoea, respiratory disorders, anaemia, asthenia, chest pain, diplopia, dizziness, eosinophilia, haemorrhage, headache, hepatic disorders, hypotension, insomnia, leucocytosis, myalgia, nasal congestion, paraesthesia, diarrhoea, nausea, vomiting, skin reactions vulvovaginal candidiasis. Rare: Angioedema, neutropenia, pancytopenia, pseudomembranous enterocolitis, seizure, thrombocytopenia, thrombocytosis, tinnitus, vertigo, toxic epidermal necrolysis.