C-SUM
CEFOPERAZONE AND SULBACTAM · by HELIX
Composition
Inj 500 mg: Sulbactam 250 mg, cefoperazone 250 mg; powder in vial.Inj 1 gm: Sulbactam 500 mg, cefoperazone 500 mg; powder in vial. Inj 2 gm: Sulbactam 1000 mg, cefoperazone 1000 mg; powder in
Indications & Dosage
Infection of respiratory tract, urinary tract, skin & soft tissue, bone & joint and intra-abdominal infections, peritonitis, cholecystitis, septicaemia, meningitis: BY IV INJ: Adults: 2-4 gm a day in equally divided doses every 12 hr, may be increased up to max 8 gm a day (equivalent to cefoperazone 4 gm a day) in severe infections. Children: 40-80 mg/kg/day in 2-4 equally divided doses, may be increased up to max 180 mg/kg/day in severe infections. Newborn infants to 1 week: 40-80 mg/kg/day every 12 hr. Max sulbactam dose in children 80 mg/kg/day. For cefoperazone dose higher than 80 mg/kg/day, given cefoperazone separately.
Contraindications
History of allergies to penicillins, cephalosporins or sulbactam.
Interactions
Physical incompatibility with aminoglycoside, doxycycline, meclofenoxate, ajmaline, hydroxyzine, pro-cainamide, aminophylline, prochlorperazine, cytochrome C, pentazocine, aprotinin.
Pregnancy
Caution advised
Lactation
Caution advised
Side Effects
Abdominal discomfort, agranulocytosis, allergic reactions, anaphylaxis, aplastic anaemia, blood disorders, confusion, disturbances in liver enzymes, dizziness, eosinophilia, haemolytic anaemia, headache, hypertonia, leucopenia, nervousness, pruritus, rashes, fever and arthralgia, sleep disturbances, urticaria, GI disturbances, Rare: Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, transient cholestatic jaundice, transient hepatitis