CABILOV
LEVODOPA AND CARBIDOPA WITH ENTACAPONE · by HELIX
Composition
Tab: Levodopa 50mg / Carbidopa 12.5mg / Entacapone 200mg Tab: Levodopa 100mg / Carbidopa 25mg / Entacapone 200mg Tab: Levodopa 200mg / Carbidopa 50mg / Entacapone 200mg
Indications & Dosage
Parkinsons disease and end-of-dose motor fluctuations not adequately controlled with levodopa and dopadecarboxylase inhibitor treatment: Adult: 1 tablet for each dose; max. 10 tablets per day or max. 7 tablets per day in case of Tab 200mg/50mg/200.
Contraindications
Severe psychosis, narrow angle glauco---_ma, history of malignant melanoma, history of neuroleptic malignant syndrome, history of non-traumatic rhabdomyolysis, phaeochromocytoma
Precautions
Hepatic and renal impairment, history of convulsions, history of myocardial infarction with residual arrhythmia, Cushings syndrome, diabetes mellitus, endocrine disorders, history of peptic ulcer ,hyperthyroidism, osteomalacia, phaeochromocytoma, psychiatric illness, severe cardiovascular disease, severe pulmonary disease, susceptibility to angle-closure glaucoma. Monitor blood values, hepatic, renal and cardiovascular function.
Interactions
Drugs affecting central amines. MAOls, oral iron, drugs that cause hypotention, antihypertensives and sympathomimetics, ferrous sulphate.
Pregnancy
Use with caution; risk of toxicity
Lactation
Contraindicated
Side Effects
Anorexia, anxiety, ataxia, arrhythmias, abnormal dreams, chorea, confusion, dementia, depression, dizziness, drowsiness, dry mouth, dyskinesia, dystonia, euphoria, fatigue, insomnia, nausea, palpitations, postural hypotension, psychosis, syncope, vomiting, chest pain, constipation, diarrhoea, dysphagia, flatulence, hand tremor, hoarseness, hypersalivation, hypertension, malaise, muscle cramps, oedema, reddish discoloration of the urine and other body fluids, weakness, weight changes, abdominal pain, hallucinations, insomnia. Rare: Myocardial infarction, ischaemic heart disease