CANREC
CANDESARTAN CILEXETIL · by MARTIN DOW MARKER
Composition
Tab 4 mg/8 mg/16 mg/32 mg: Candesartancilexetil 4 mg/8 mg/16 mg/32 mg.
Indications & Dosage
Hypertension: Adult: Initially 8 mg once daily, increased if necessary up to 32 mg once daily, increased at intervals of 4 weeks; usual dose 8 mg once daily. Children 6-18 yrs: initially 4 mg once daily (reduced dose in intravascular volume depletion), adjusted according to response, max 8 mg once daily. Hypertension with intravascular volume depletion: Adult: Initially 4 mg once daily, increased if necessary up to 32 mg daily, increased at intervals of4 weeks; usual dose 8 mg once daily. Heart failure with impaired left ventricular systolic function when ACE inhibitors are not tolerated or in conjunction with an ACE inhibitor: Adult: Initially 4 mg once daily, increased at intervals of at least 2 weeks to required dose of 32 mg once daily or to max. tolerated dose.
Contraindications
Severe hepatic impairment, cholestasis.
Precautions
Correct volume/salt depletion before starting ther-apy, anaesthesia, renal impairment; monitor serum potassium and creatinine, severe renal impairment, haemodialysis; carefully titrate dose and monitor BP thoroughly, renal artery stenosis, aortic or mitral stenosis, kidney transplant, obstructive hypertrophic cardiomyopathy, severe congestive heart failure, mild to moderate hepatic impairment, primary hyperaldosteronism.
Interactions
K+-sparing diuretics, K+-supplement, lithium.
Pregnancy
Contraindicated in pregnancy.
Lactation
Not recommended.
Side Effects
Headache, vertigo. Rare: Arthralgia, back pain, blood disorders, cough, hepatitis, hyponatraemia, myalgia, nausea, pruritus, rash, urticaria