Composition
Inj 0.25 gm/0.5 gm/1 gm/2 gm: Cefoperazone0.25 gm/0.5 gm/1 gm/2 gm (as sodium); powder in vial and ampoule containing solvent.
Indications & Dosage
Severe infections of gram-negative or from mixed flora in the presence of gram-negative bacteria, resistant to other antibiotics: BY IM OR IV INJ: Adults: 1-2 gm twice daily, adult dose may be doubled if administered by IV. Max 9 gm daily in divided doses. Children & Infants: 50-200 mg/kg/day given in two or more administrations. For neonates (less than 8 days), the drug should be given every 12 hr.
Administration
Inject deep IM Into large muscle mass. IV: Inject direct IV over 3-5 min. Infuse intermittent infusion over 30 min. Reconstitute with required amount of diluent. Then further dilute in compatible solution. IM: Reconstitute drug with bacteriostatic water for injection (that contains benzyl alcohol or parabens) or SWFI. After reconstitution, let foam dissipate and inspect the solution to ensure complete dissolution.
Compatibility
Bacteriostatic water for injection, D5LR, D51/4 NS, D5NS, D5W; D1OW, LR, NS, and SWFI.
Stability
Prior to reconstitution, store at room temperature.Protect from light. Reconstituted and IV infusion in NS or D5W solution are stable for 24 hours at room temperature , 5 days when refrigerated or 3 weeks, when frozen. After freezing, thawed solution is stable for 48 hours at room tem-perature or ten days when refrigerated.
Precautions
Prolong use may lead to super infection, may interfere with haemostasis, may cause colitis.
Interactions
Probenecid, furosemide, aminoglycoside.
Pregnancy
Caution advised
Lactation
Caution advised
Side Effects
Abdominal discomfort, agranulocytosis, allergic reactions, anaphylaxis, aplastic anaemia, blood disorders, confusion, disturbances in liver enzymes, dizziness, eosinophilia, haemolytic anaemia, headache, hypertonia, leucopenia, nervousness, pruritus, rashes, fever and arthralgia, sleep disturbances, urticaria, GI disturbances. Rare: Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, transient cholestatic jaundice, transient hepatitis,