Composition
Tab: Medroxyprogesterone acetate 500 mg
Indications & Dosage
Breast carcinoma: Adult: 0.4-1.5 gm daily orally. Endometrial and renal carcinoma: Adult: 200-600 mg daily. Prostatic carcinoma: Adult: 100-600 mg daily.
Contraindications
Severe arterial disease, undiagnosed vaginal bleeding and acute porphyria, history during pregnancy of idiopathic jaundice, severe pruritus, or pemphigoid gestations, incomplete miscarriage, missed miscarriage. Avoid in hepatic impairment. Avoid in active liver disease including disorders of hepaticexcretion (e.g. Dublin-Johnson or Rotor Syndromes), infective hepatitis (until liver function returns to normal) and liver tumours and lactation
Precautions
Renal impairment, conditions that may worsen with fluid retention, epilepsy, hypertension, migraine, asthma, or cardiac dysfunction, susceptible to thromboembolism (particular caution with high dose, history of depression. Progestogens can decrease glucose tolerance and patients with diabetes should be monitored closely.While using as contraceptive wait 6 weeks post-partum if lactating.
Interactions
Rifamycin, anticoagulants, antidepressants, anti-diabetics, anti-epileptics, antifungals, antivirals, aprepitant, barbiturates, bosentan, cyclosporin, diuretics, dopaminergics, lipid-regulating drugs, muscle relaxants.
Side Effects
Transient infertility on continuous treatment, irregular, prolonged or heavy vaginal bleeding during first 2 or 3 cycles, menstrual disturbances, premenstrual-like syndrome (including bloating, fluid retention, breast tenderness), weight change, nausea, headache, dizziness, insomnia, drowsiness, depression, change in libido; also skin reactions (including urticaria, pruritus, rash, and acne), hirsutism, alopecia, jaundice and anaphylactoid reactions