CO-BARITEC
OLMESARTAN MEDOXOMIL AND HYDROCHLOROTHIAZIDE · by BARRETT HODGSON
Composition
Tab 20/12.5 mg:Olmesartan medoxomil 20 mg, hydrochlorothiazide 12.5 mg. Tab 20/25 mg:Olmesartan medoxomil 20 mg, hydrochlorothiazide 25 mg. Tab 40/12.5 mg:Olmesartan Medoxomil 40 mg, hydrochl
Indications & Dosage
Hypertension in patients stabilised on the individual components in the same proportions, or not adequately controlled with olmesartan and amlodipine: Adults: 1 tab daily using the strength as clinically appropriate. Children: Not recommended.
Contraindications
Hepatic or severe renal impairment, cholestasis, biliary obstructive disorders, refractory hypoka-laemia, hypercalcaemia, hyponatraemia, symptomatic hyperuricaemia.
Precautions
Salt or volume depletion, severe congestive heart failure, renal disease, renal artery stenosis, aortic or mitral valve stenosis, obstructive hypertrophic cardiomyopathy, primary aldosteronism, diabetes, mild to moderate renal impairment; monitor serum electrolytes, creatinine and uric acid.
Interactions
Lithium, K-supplement, K+-sparing diuretics, salt substitutes, baclofen, NSAIDs, amifostine, alcohol, CNS depressants, laxatives, corticosteroids, ACTH, amphotericin, carbenoxolone, penicillin G, salicylic acid derivatives, calcium supplement, cholestyramine, colestipol, cardiac glycosides, drugs prolonging QT interval or causing torsade de pointes, tubocurarine, anticholinergics, antidiabetic agents, metformin, beta-blockers, diazoxide, uricosuric agents.
Pregnancy
Contraindicated in pregnancy.
Lactation
Not recommended.
Side Effects
Arthritis, chest pain, cough, fatigue, GI disturbances, haematuria, hypertriglyceridaemia, hyperuricaemia, influenza-like symptoms, musculoskeletal pain, peripheral oedema, pharyngitis, rhinitis, urinary-tract infection. Rare: Angina, vertigo, headache, myalgia, pruritus, thrombocytopenia, urticaria