CO-LOSARTIN
LOSARTAN AND HYDROCHLOROTHIAZIDE · by TAGMA
Composition
Tab 50/12.5 mg: Losartan potassium 50 mg, hydrochlorothiazide 12.5 mg. Tab 100/12Z mg: Losartan potassium 100 mg, hydrochlorothiazide 12.5 mg. Tab 100/25 mg: Losartan potassium 100 mg, hydroc
Indications & Dosage
Hypertension not adequately controlled with losartan alone: Adults: Initially 1 tab daily, increased to max 100 mg losartan daily if necessary. CHILDREN: Not recommended.
Contraindications
Hepatic impairment, anuria, moderate to severe renal impairment, dialysis, intravascular volume depletion.
Precautions
Hepatic impairment, renal impairment, intravascular volume depletion, renal artery stenosis, obstructive valvular disease, aortic stenosis, outflow obstruction, cardiomyopathy, SLE, gout, obstructive valvular disease. Monitor serum electrolytes
Interactions
Barbiturates, narcotics, antidiabetic agents, cholestyramine, colestipol, corticosteroids, ACTH, adrenaline, muscle relaxants, lithium, NSAIDs, K+-sparing diuretics, rifampicin, fluconazole.
Pregnancy
Contraindicated in pregnancy.
Lactation
Not recommended.
Side Effects
Hyperkalaemia, angioedema, symptomatic hypotension including dizziness particularly in patients with intravascular volume depletion, e.g. those taking high-dose diuretics,, arthralgia, rhinitis, flatulence, orthostatic effects, diarrhoea, liver function abnormalities, myalgia, hypertriglyceridaemia, migraine, urticaria, pruritus, rash. Rare: Anaphylactic reactions, angioedema, vasculitis, hepatitis, cough, anaemia