CO-VALID
VALSARTAN AND HYDROCHLOROTHIAZIDE · by SCILIFE
Composition
Tab80/12.5 mg: Valsartan 80 mg, hydrochlorothiazide 12.5 mg. Tab160/12.5 mg: Valsartan 160 mg, hydrochlorothiazide 12.5 mg. Tab160/25 mg: Valsartan 160 mg, hydrochlorothiazide 25 mg.
Indications & Dosage
Hypertension not adequately controlled by valsartan alone: Adults: 1 tab daily using the strength as clinically appropriate. Children: Not recommended.
Contraindications
Severe renal or hepatic impairment, cirrhosis, biliary obstruction, renal artery stenosis, anuria, conditions or treatments predisposing to potassium loss.
Precautions
Mild to moderate hepatic impairment, salt or volume depletion, SLE. Monitor serum electrolytes.
Interactions
Lithium, corticosteroids, K+-sparing diuretics or K+ supplements, heparin, muscle relaxants, cyclosporin, hypoglycaemic agents, NSAIDS, methotrexate, cyclophosphamide, pressor amines, allopurinol, digitalis, calcium supplements, diazoxide, anticholinergics, insulin, carbenoxclone, penicillin G, salicylic acid, Vit D analogue, cholestyramine, colestipol, alcohol, barbiturates, narcotics.
Pregnancy
Contraindicated in pregnancy.
Lactation
Not recommended.
Side Effects
Renal impairment, cough, fatigue, GI disturbance, headache, syncope, hypersensitivity reactions, myalgia, neutropenia, pruritus, rash, serum sickness, thrombocytopenia, vasculitis