Composition
Tab 5 mg/10 mg/20 mg: Memantine HCI 5 mg/10 mg/20 mg. Oral Soln: Per 5 ml: Memantine 10 mg.
Indications & Dosage
Moderate to severe dementia in Alzheimers disease: Adult: Initially 5 mg once daily, then increased in steps of 5 mg every week; usual maintenance 20 mg daily; max. 20 mg per day. Children: Not recommended.
Contraindications
Severe renal impairment.
Precautions
Moderate renal, hepatic impairment, epilepsy or predisposition to epilepsy, history of convulsions, recent MI, uncompensated heart failure, uncontrolled hypertension.
Interactions
Amantadine, ketamine, dextromethorphan, levodopa, dopaminergic agonists, anticholinergics, barbitu-rates, neuroleptics, baclofen, dentrolene, cimetidine, ranitidine, procainamide, quinidine, quinine, nicotine, hydrochlorothiazide.
Pregnancy
Caution advised
Lactation
Caution advised
Side Effects
Balance disorders, constipation, dizziness, drowsiness, dyspnea, headache, depression, hypertension, abnormal gait, confusion, fatigue, tiredness, hallucinations, heart failure, thrombosis, vomiting Rare: Seizures, hepatitis, pancreatitis, psychosis, suicidal ideation Prices: