Composition
Cap 100mg: Isavuconazole 100mg Inf: Isavuconazole 200mg powder for solution for infusion vials
Indications & Dosage
Invasive aspergillosis, Mucormycosis in patients for whom amphotericin B is inappropriate: ORAL, OR BY IV INF: Adult: Loading dose 200 mg every 8 hours for 48 hours (6 administrations in total), then maintenance 200 mg once daily, maintenance dose to be started at least 12 hours after the last loading dose; long-term treatment should be reviewed after 6-months.
Administration
For IV Infusion reconstitute each 200 mg with 5 ml Water for Injection; dilute dose to concentration of 0.8 mg/ml with Glucose 5% or Sodium Chloride 0.9% and give via a 0.2–1.2 micron filter over at least 1 hr.
Stability
Store in refrigerator (2–8 C) consult product literature for storage after reconstitution or dilution.
Contraindications
Acute porphyrias, short QT syndrome
Precautions
Elderly, caution in severe hepatic impairment; toxicity with related drugs. Monitor liver function
Interactions
Antifungals, azoles, CYP3A4/5 inducers (eg, rifamycins, carbamazepine, phenytoin, St Johns wort), inhibitors (eg, ketoconazole, protease inhibitors) or substrates (eg, immunosuppressants). Substrates of BCRP, CYP34, CYP2B6, P-gp, UGT or OCT2. Drugs that shorten QT interval.
Pregnancy
Avoid unless severe or life-threatening infection
Lactation
Avoid
Side Effects
Asthenia, arrhythmias, confusion, depression, delirium, diarrhoea, dizziness, dyspnoea, electrolyte imbalance, GI discomfort, hepatic disorders, hyperbilirubinaemia, nausea, respiratory disorders, skin reactions, thrombophlebitis, vomiting, taste altered, appetite decreased, encephalopathy, hypersensitivity, hypoalbuminaemia, leucopenia, malaise, palpitations, pancytopenia, paraesthesia. Rare: Alopecia anaemia, circulatory collapse, peripheral neuropathy, peripheral oedema, seizures, syncope, thrombocytopenia, vertigo, severe cutaneous adverse reactions (SCARs), renal failure, haemorrhage, neutropenia.