Composition
Cap 250 mg: Crizotinib 250 mg
Indications & Dosage
Anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer, ROS1-positive advanced non-small cell lung cancer: Adult: 250 mg twice daily, consult product literature for information on dose adjustments.
Administration
May be administered IV, IM, or SC. IM inj should be given as a deep into a large muscle. IV infusion in 50250 ml of D5W or NS over at least 60 min; a small test dose (0.1 ml of dilute 20 unit/ml solution) should be given first. Lyophilized powder should be reconstituted with 1-5 ml SWFI for IV administration or NS for IM use
Stability
Stable in NS, D5W.Store intact vial in refrigerator, reconstituted solution should be stored under refrigeration and can be used within 8 hours as long as the solution is clear. If the solution becomes turbid, it should be discarded.
Contraindications
Gastrointestinal perforation
Precautions
History of diverticulitis, metastases of gastrointestinal tract, patients with susceptibility to QT prolongation (including bradycardia, history of cardiac disease, concomitant use of drugs that prolong QT interval, and electrolyte disturbances); periodic renal monitoring required, risk of gastro-intestinal perforation, vision disorders reported; full ophthalmological evaluation if vision disorder worsens or persists, moderate to severe renal impairment, moderate to severe hepatic impairment. Ensure effective contraception during and for at least 90 days after treatment.
Interactions
Dexamethasone.
Pregnancy
Avoid
Lactation
Avoid. Discontinue breast-feeding.
Side Effects
Anaemia, arrhythmias, constipation, diarrhoea, dizziness, fatigue, gait abnormal, GI disorders, heart failure, hepatic function Abnormal, hypogonadism, hypophosphataemia, leucopenia, local swelling, movement disorders, muscle atrophy, muscle tone decreased, muscle weakness, nausea, nerve disorders, neuralgia, neurotoxicity, neutropenia, oedema, periorbital oedema, peroneal nerve palsy, pulmonary oedema, QT interval prolongation, renal abscess, renal cyst, respiratory disorders, sensation abnormal, skin reactions, syncope, vision disorders, vitreous floater . vomiting. Rare: GI perforation, hepatic failure, renal impairment