Composition
Inj 3.5 mg: Bortezomib 3.5 mg
Indications & Dosage
Multiple myeloma, Mantle cell lymphoma: BY IV INJ, OR BY SC INJ: Adult: Specialist use only. (Consult product literature or local protocols).
Contraindications
Acute diffuse infiltrative pulmonary disease, pericardial disease
Precautions
Moderate to severe hepatic impairment; monitor for toxicity, renal impairment, amyloidosis, cardiovascular disease, tiviral prophylaxis for herpes zoster infection, dehydration, diabetes, history of syncope, pulmonary disease, risk factors for seizures, risk of neuropathy. Monitor blood-glucose concentration in patients on oral antidiabetics. Monitor for symptoms of progressive multifocal leukoencephalopathy. Chest x-ray recommended before treatment to monitor for pulmonary disease.
Interactions
Clopidogrel, Dasatinib, Deferasirox, Peginterferon Alfa-2b, CYP2C19 inducers and inhibitors, CYP3A4 inducers and inhibitors.
Pregnancy
Use only if essential
Lactation
Avoid. Discontinue breast-feeding.
Side Effects
Anaemia, anxiety, arrhythmias, asthenia, chills, constipation, decreased leucocytes, diabetes mellitus, diarrhoea, dizziness, dysphagia, dyspnoea, electrolyte imbalance, encephalopathy, enzyme abnormality, eye inflammation, fever, fluid imbalance, GI disorder, haemorrhage, hair disorder, headaches, hearing impairment, heart failure, hepatic disorders, hiccups, hyperbilirubinaemia, hypersensitivity, hypertension, hypotension, ischaemic heart disease, lethargy, loss of consciousness, confusion, malaise, nausea, nerve disorders, neuromuscular dysfunction, neutropenia, oedema, oral disorders, oropharyngeal complaints, pain, renal impairment, sepsis, syncope, thrombocytopenia, tinnitus, ventricular dysfunction, vertigo, vision disorders, vomiting. Rare: Angioedema, cardiovascular disorders, cerebrovascular insufficiency, posterior reversible encephalopathy syndrome (PRES) (discontinue), proteinuria, psychiatric disorders, acidosis, acute coronary syndrome, blood disorders, bone disorder, brain oedema, CNS haemorrhage, cognitive disorder, coma, sudden death, suicidal ideation, herpes zoster reactivation, progressive multifocal leukoencephalopathy (PML)