DANOCRINE
DANAZOL · by SANOFI-AVENTIS
Composition
Cap 100 mg/200 mg: Danazol 100 mg/200 mg.
Indications & Dosage
Endometriosis: Adult: 200-800 mg daily in up to 4 divided doses usually for 3-6 months, adjusted to achieve amenorrhoea, in women of child-bearing potential, treatment should start during menstruation, preferably on day 1. Severe pain and tenderness in benign fibrocystic breast disease not responding to other treatment: Adult: 300 mg daily in divided doses usually for3-6 months, in women of child-bearing potential, treatment should start during menstruation, preferably on day 1. Hereditary angioedema: Adult: Initially 100-200 mg daily, reduced according to response, in women of child-bearing potential, treatment should start during menstruation, preferably on day 1.
Contraindications
Porphyria, thromboembolic disease, undiagnosed genital bleeding, androgen dependent tumours.
Precautions
Severe hepatic, cardiac and renal dysfunction, epilepsy, migraine, diabetes, susceptibility to weight gain, elderly, history of thrombosis or thromboembolic disease, hypertension, lipoprotein disorder, polycythaemia
Interactions
Oral contraceptives, anticoagulants, carbamazepine, cyclosporin.
Pregnancy
Contraindicated in pregnancy.
Lactation
Contraindicated, avoid
Side Effects
Nausea, dizziness, rashes, back ache, flushing, muscle spasm, androgenic effects, weight gain, fluid retention, headache, emotional lability, cholestatic jaundice, benign intracranial hypertension.