DAONIL
GLIBENCLAMIDE · by SANOFI-AVENTIS
Composition
Tab 2.5 mg/5 mg: Glibenclamide 2.5 mg/5 mg.
Indications & Dosage
Type 2 Diabetes mellitus, maturity-onset diabetes mellitus: Adult: Initially 5 mg daily, adjusted according to response, dose to be taken with or immediately after breakfast; max. 15 mg per day. Children: Not recommended.
Contraindications
Acute porphyria, renal and hepatic disease, diabetic coma insulin-dependent diabetes.
Precautions
Cross-sensitivity to sulfonamides and sulfonamide derivative. Not licensed for use in breast feeding women with pre-existing diabetes and gestational diabetes
Interactions
Potentiation of hypoglycaemic effects with alcohol, beta-blockers, bezafibrate, biguanides, chloramphenicol, clofibrate, coumarin derivatives, MAOIs, salicylates, tetracyclines, attenuation and aggravation of metabolic states by laxatives, corticosteroids, nicotinic acid, oestrogens, phenothiazine derivatives, saluretics, sympathomimetics, thyroid hormones
Pregnancy
Not recommended
Lactation
Contraindicated or not recommended.
Side Effects
Thrombocytopenia, aplastic anemia, hemolytic anemia, cholestatic jaundice, fictitious hypoglycaemia, agranulocytosis, hepatitis, nausea and sensation of fullness, transient visual disturbance, blood dyscrasias.