DEMENTIO
GALANTAMINE HYDROBROMIDE · by GENETICS
Composition
Tab 4 mg/8 mg/12 mg:Galantamine (as hydrobromide) 4 mg/8 mg/12 mg. Oral Soln: Per 5 ml: Galantamine (as hydrobromide) 4 mg.
Indications & Dosage
Mild to moderately severe dementia in Alzheimers disease: Adult: Initially 4 mg tab twice daily for 4 weeks, increased to 8 mg twice daily for at least 4 weeks; maintenance 8-12 mg twice daily; alternatively, initially 8 mg ER tab once daily for 4 weeks, increased to 16 mg ER tab once daily for at least 4 weeks; maintenance 16-24 mg ER tab daily.
Contraindications
Severe hepatic or renal impairments. Avoid in GI obstruction, urinary outflow obstruction, whilst recovering from bladder or GI surgery
Precautions
Moderate hepatic impairment, cardiac disease, chronic obstructive pulmonary disease, congestive heart failure, electrolyte disturbances, history of seizures, history of severe asthma, pulmonary infection, sick sinus syndrome, supraventricular conduction abnormalities, susceptibility to peptic ulcers, unstable angina, recent MI, atrial fibrillation, 2nd degree AV block, cerebrovascular disease, increased risk of peptic ulcer, epilepsy, asthma, COPD, pulmonary infection, Monitor body-weight.
Interactions
Cholinomimetics, anticholinergics, CYP2D6 or 3A4 inhibitors. Digoxin, beta-blockers, calcium antagonists, amiodarone. Depolarising muscle relaxants
Pregnancy
Caution advised
Lactation
Contraindicated
Side Effects
Arrhythmias, blurred vision, dehydration, bradycardia, headache, loss of appetite, depression, diarrhoea, dizziness, dyspepsia, fatigue, hallucination, hypertension, malaise, muscle spasm, nausea, syncope, tremor, vomiting, weight loss, first-degree AV block, flushing, hypotension, muscular weakness, palpitation, paraesthesia, retching, hypersomnia, seizures, sweating, taste disturbance, tinnitus