Composition
Tab: Deucravacitinib 6 mg
Indications & Dosage
Treatment of moderate to severe plaque psoriasis in adult candidate for systemic therapy or phototherapy: Adult: 6 mg once daily, dose should be taken at the same time every day with or without meal.
Contraindications
Severe hepatic impairment (Child-Pugh C), hypersensitivity reaction (angioedema).
Precautions
Increased risk of infection, evaluate patients for tuberculosis prior to initiating treatment if positive consider treating tuberculosis before starting Deucravacitinib. Periodically evaluate serum triglyceride level and liver enzymes levels.
Interactions
Aliskiren, Antacids, Antiarrhythmics, Antiepileptics, Antifungals, azoles, non-sedating antihistamines, Aprepitant, Calcium channel blockers, ciclosporin, Cobicistat, colchicine, Coumarins (warfarin), Crizotinib, dabigatran, digoxin, edoxaban, Enzalutamide, ergotamine, everolimus, Grapefruit juice (avoid), H2 receptor antagonists, HIV-protease inhibitors, Idelalisib, Imatinib, Lapatinib, loperamide, Macrolides, Netupitant, Nilotinib, NSAIDs, Opioids, pimozide, Proton pump inhibitors, Ranolazine, Rifampicin, sirolimus. St Johns Wort, sulfonylureas (glimepiride). Tacrolimus, Taxanes, topotecan.
Pregnancy
Avoid unless essential
Lactation
Contraindicated. Discontinue breast-feeding
Side Effects
Increased risk of infection, Malignancy including lymphoma, upper respiratory infection, herpes simplex, mouth ulcer, increased triglyceride level, increased liver enzymes