Composition
Tab 12.5 mg/25 mg/50 mg: Hydrochlorothiazide 12.5 mg/25 mg/50 mg.
Indications & Dosage
Hypertension: Adults: Initially 12.5 mg once daily, max 50 mg/day. Children below 6 months: 1-3 mg/kg/ day in 2 divided doses; 6 months-2 yrs: 1-3 mg/kg/day in 2 divided doses, max 37.5 mg/day; 2-18 yrs: 1 mg/kg/day, max 3 mg/kg/day (50 mg/day). Oedema: Adult: 25-100 mg/day in 1-2 divided doses, max 200 mg/day. Elderly: 12.5-25 mg once daily. Children below 6 months: 1-3 mg/kg/ day in 2 divided doses; 6 months-2 yrs: 1-3 mg/kg/day in 2 divided doses, max 37.5 mg/day; 2-18 yrs: 1 mg/kg/day, max 3 mg/kg/day (50 mg/day). Heart Failure: Adult: 25-100 mg daily to be given every alternate day or 3-5 day per week. Children: 1-2 mg/kg/day given once daily or twice daily. Max dose below 6 months: 1.5 mg/kg twice daily; below 2 yrs: 37.5 mg/day;2-12 yrs: 100 mg/day.
Contraindications
Addisons disease, hypercalcaemia, hyponatraemia, refractory hypokalaemia, symptomatic hyperuricaemia, anuria, renal decompensation.
Precautions
Diabetes, gout, hyper-aldosteronism, malnourishment, nephrotic syndrome, systemic lupus erythematosus, avoid in severe renal disease, patients with moderate to high cholesterol concentrations.
Interactions
Beta-blockers, ACE inhibitors, neuromuscular blocking agents, oral hypoglycaemics, NSAIDs.
Pregnancy
Contraindicated in pregnancy.
Lactation
Not recommended.
Side Effects
Altered plasma-lipid concentrations, gout, hypercalcaemia, hyperglycaemia, hyperuricaemia, hypochloraemic alkalosis, hypokalaemia, hypomagnesaemia, hyponatraemia, metabolic and electrolyte disturbances, mild GI disturbances, postural hypotension, anorexia, epigastric distress.