DOWVIR
SOFOSBUVIR AND VELPATASVIR · by MARTIN DOW
Composition
Each film-coated tablet Contains: Sofosbuvir 400mg and Velpatasvir 100mg
Indications & Dosage
Chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5, or 6 infection without cirrhousis or with compensated cirrhosis, in combination with ribavirin with decompensated cirrhosis: Adult: 400/100 mg once daily for 12 weeks; may extend to 24 weeks if required (consult product literature).
Precautions
Hepatitis B co-infection, renal impairment, decompensated cirrhosis, patients awaiting liver transplantation. Serious symptomic bradycardia may occur in patients taking amiodarone, particularly in patients also receiving beta blockers, or those with underlying cardiac comorbidities and/or advance liver disease.
Interactions
Telaprevir, boceprevir, other direct-acting HCV antivirals. Modafinil, potent P-gp inducers
Pregnancy
Avoid
Lactation
Avoid
Side Effects
Agitation, alopecia, anaemia, anxiety, arthralgia, asthenia, blurred vision, chest pain, constipation, decreased appetite, depression, diarrhoea, dizziness, dry mouth, dyspnea, gastro-oesophageal reflux, abdominal discomfort, headache, influenza-like symptoms, insomnia, irritability, memory impairment, migraine, myalgia, nausea, neutropenia, rash, vomiting, weight loss