DOXAGIT
DOXAZOSIN MESYLATE · by GLITZ
Composition
Tab 1 mg/2 mg/4 mg: Doxazosin (as mesylate) 1 mg/2 mg/4 mg.
Indications & Dosage
Urinary outflow obstruction and symptoms associated with benign prostatic hyperplasia: Adults: Initially 1 mg once daily, increasing if necessary after 1-2 week to 2 mg once daily, and then 4 mg once daily if required; max 8 mg daily for urinary outflow obstruction & symptoms associated with BPH. Hypertension: Adult: Initially 1 mg once daily, may be increased to double the dose every 1-2 week. Max: 8 mg/day. Children: Not recommended.
Contraindications
History of postural hypotension and micturition syncope.
Precautions
Care with initial dose (postural hypotension); monitor BP regularly, cataract surgery (risk of intra-operative floppy iris syndrome), elderly, heart failure, pulmonary oedema due to aortic or mitral stenosis, hepatic and renal impairment
Interactions
Beta-blockers, diuretics, ACE inhibitors, calcium channel blockers, sildenafil, tadalafil, vardenafil.
Pregnancy
Risk cannot be ruled out.
Lactation
Contraindicated, avoid
Side Effects
Anxiety, back pain, coughing, dyspnea, fatigue, influenza-like symptoms, myalgia, paraesthesia, sleep disturbance, vertigo, agitation, angina, arthralgia, epistaxis, gout, hypoaesthesia, micturition disturbance, myocardial infarction, tinnitus, tremor, weight changes, angioedema, asthenia, blurred vision, depression, dizziness, drowsiness, dry mouth, erectile disorders, GI disturbances, headache, hypersensitivity, hypotension, intra-operative floppy iris syndrome, oedema, palpitations, postural hypotension, priapism, pruritus, rash, rhinitis, syncope, tachycardia