DUOTRAV
TRAVOPROST AND TIMOLOL · by NOVARTIS
Composition
Eye Drop: Per ml: Travoprost 40 mcg and Timolol 5 mg; 2.5 ml
Indications & Dosage
Raised intra-ocular pressure in patients with open-angle glaucoma or ocular hypertension when beta-blocker or prostaglandin analogue alone not adequate: Adult: Apply once daily, preferably in the evening.
Contraindications
Sinus bradycardia, 2nd or 3rd degree AV block, uncompensated cardiac failure, cardiogenic shock, hypotension, severe Raynauds disease, unstable angina, asthma history of obstructive pulmonary disease, soft contact lenses.
Precautions
History of significant ocular viral infections, angle-closure glaucoma, aphakia, asthma, chronic obstructive pulmonary disease, compromised respiratory function, congenital glaucoma, contact lens wearers, inflammatory ocular conditions, narrow-angle glaucoma, neovascular glaucoma, pseudophakia with torn posterior lens capsule or anterior chamber lenses, risk factors for cystoid macular oedema, iritis or uveitis. Monitor eye condition closely particularly with dry eyes or if cornea is compromised. Hepatic and renal impairment, sick sinus syndrome, metabolic acidosis, 1st degree AV block, history of severe cardiac disease, hyperthyroidism, diabetes. Advise patient to report any inter current ocular condition. Monitor cardiac function and treatment following filtration procedures. Withdraw gradually.
Interactions
Floctafenine, amiodarone, MAOIs, verapamil, diltiazem, nifedipine, antihypertensives, adrenaline, oral Beta-blockers, digoxin, disopyramide, lidocaine, quinidine, clonidine, insulin, oral hypoglycaemics. Leave interval of 5 min, before using other eye preps, and 15 min, before inserting contact lenses.
Pregnancy
Avoid
Lactation
Not recommended, avoid
Side Effects
Asthenopia, ocular discomfort, headache, dizziness, blepharitis, blood pressure changes, conjunctival disorders, corneal erosion, darkening, thickening and lengthening of eye Lashes, eyelash and vellus hair changes, photophobia, pigmentation of periocular skin, punctate keratitis, reduced visual acuity, transient blurred vision, bronchospasm, exacerbation of myasthenia gravis, GI and CNS disturbances, rash, systemic beta-blocker effects. Rare: Arthralgia, darkening of palpebral skin, facial oedema