Composition
Tab 25 mg/50 mg: Eplerenone (HCl) 25 mg/50 mg.
Indications & Dosage
Adjunct in stable patients with left ventricular ejection fraction 40% or less with evidence of heart failure following myocardial infarction (start therapy within 3-14 days of event), Adjunct in chronic mild heart failure with leftventricular ejection fraction 30% or less: Adult: Initially 25 mg daily, then increased to 50 mg daily, increased within 4 weeks of initial treatment. Children: Not recommended.
Contraindications
Concomitant use of potassium-sparing diuretics or potassium supplements, hyperkalaemia, severe hepatic impairment.
Precautions
Monitor plasma potassium concentration before, during and after treatment. Adjust dose according to serum-potassium concentration in renal impairment, elderly.
Interactions
ACE inhibitors, angiotensin II antagonists, potassium sparing diuretics, potassium supplements, CYP3A4 inhibitors, NSAIDs.
Pregnancy
Risk cannot be ruled out.
Lactation
Caution advised or effect undetermined.
Side Effects
Azotaemia, constipation, cough, diarrhoea, dizziness, hyperkalaemia, hypotension, muscle spasm, musculoskeletal pain,nausea,pruritus, renal impairment, syncope, flatulence, vomiting, rash, atrial fibrillation, postural hypotension, arterial thrombosis, dyslipidaemia, pharyngitis, headache, insomnia, gynaecomastia, pyelonephritis, hyponatraemia, dehydration, eosinophilia, asthenia, malaise, leg cramps, sweating and pruritus.