ERYBRON
ERYTHROMYCIN AND BROMHEXINE · by INDUS PHARMA
Composition
Susp: Per 5 ml: Erythromycin ethylsuccinate equiv to 200 mg of erythromycin, bromhexine HCI 4 mg; powder for reconstitution. Tab: Erythromycin stearate equiv to 500 mg erythromycin,
Indications & Dosage
Susceptible infections in patients with penicillin hypersensitivity including respiratory-tract infections, skin and oral infections, and campylobacter enteritis (with mucolytic and expectorant actions): Adults & Children above 12 yrs: 1 tab twice daily may be increased in severe infections to 1 tab 3 or 4 times daily, to be taken before a meal. Children: Below 4 months (under 5 kg body wt): 1/2 tsp twice daily; 4 months-1 yr (5-10 kg body wt): 1 tsp twice daily; 1-6 yrs (10-25 kg body wt): 1 tsp 3 or 4 times daily; 6-12 yrs (over 25 kg body wt): 2 tsp 2 or 3 times daily.
Contraindications
Porphyria.
Precautions
Predisposition to prolonged QT interval, renal or hepatic impairment, myasthenia gravis.
Interactions
Amisulpride, tolterodine, astemizole, mizolastine, ergot derivatives, theophylline, carbamazepine, oral anticoagulants, digoxin, cisapride, alfentanil, bromocriptine, cyclosporin, disopyramide, amiodarone, hexobarbitone, midazolam, phenytoin, triazolam, valproate, statins, zopiclone, tacrolimus, pimozide, quinidine, rifabutin.
Pregnancy
No evidence of harm
Lactation
Caution advised
Side Effects
Dyspepsia, headache, diarrhoea, GI disturbances, cholestatic jaundice, allergic reactions, reversible hearing loss, pancreatitis, cardiac effects, myasthenia-like syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis.