ETHOMID
ETHIONAMIDE · by SCHAZOO ZAKA
Composition
Tab: Ethionamide 250 mg.
Indications & Dosage
Treatment of tuberculosis, and other mycobacterial diseases, in conjunction with other drugs: Adults: 500-1000 mg/day in 1-3 divided doses. Children: 15-20 mg/kg/day in 2-3 divided doses, not to exceed 1 gm/day.
Contraindications
Severe hepatic impairment; hypersensitivity to ethionamide or any component.
Precautions
Use with caution in patients receiving cycloserine or isoniazid or in diabetic patients.
Interactions
Cycloserine and isoniazid may increase nervous system adverse effects; alcohol (associated with psychotic reaction). Increase dietary intake of pyridoxine to prevent neurotoxic effects of Ethionamide.
Pregnancy
Caution advised, use only if potential benefit outweighs risk
Lactation
Caution advised
Side Effects
Anaphylactoid reactions, anorexia, nausea, vomiting, abdominal distress, postural hypotension, drowsiness, dizziness, seizures, headache, encephalopathy, depression, rash, hypoglycaemia, goiter, gynaecomastia, thrombocytopenia, hepatitis, jaundice, elevated AST, ALT and serum bilirubin, peripheral neuropathy, tremor, optic neuritis, diarrhoea, stomatitis, metallic taste, weight loss, excessive salivation.