Composition
Inj 40 mg: Per 3 ml: Phloroglucinol 40 mg; solution amp. Tab 80 mg: Phloroglucinol 80 mg.
Indications & Dosage
Smooth muscle spasm, biliary spasm, GI motility disorder, urinary spasm, uterine spasm: ORAL: Adults: 1 tab three times daily; max 6 tab daily. BY INJ: Adults: 1-3 amp daily Children: Not recommended.
Contraindications
Myasthenia gravis (but may be used to decrease muscarinic side-effects of anticholinesterases), paralytic ileus, coma, stupor pyloric stenosis, toxic megacolon, and prostatic enlargement, hypersensitivity to drug..
Precautions
Downs syndrome, elderly, gastro-esophageal reflux disease, diarrhoea, acute myocardial infarction, hypertension ulcerative colitis, autonomic neuropathy, conditions characterized by tachycardia (including hyperthyroidism, cardiac insufficiency, cardiac surgery), pyrexia, and in individuals susceptible to angle-closure glaucoma.
Interactions
Amantadine, phenothiazines atenololdigoxin, tricyclic antidepressants.
Pregnancy
Contraindicated
Lactation
Not recommended.
Side Effects
Hypotension, angioneurotic oedema, urticaria, Constipation, transient bradycardia (followed by tachycardia, palpitation and arrhythmias), reduced bronchial secretions, urinary urgency and retention, dilatation of the pupils with loss of accommodation, photo-phobia, dry mouth, flushing and dryness of the skin, nausea, vomiting, and giddiness. Rare: Angle-closure glaucoma may occur.