Composition
Inj: Colfosceril palmitate 108 mg; powder in vial plus diluent and adapters.
Indications & Dosage
Prophylaxis & treatment of neonatal respiratory distress syndrome (RDS): BY ENDOTRACHEAL TUBE: 5 ml/ kg as soon as the diagnosis of RDS or risk of RDS is established; the second and third dose should be administered 12 and 24 hrs later to those infants remaining on ventilators.
Administration
For intratracheal administration only. Suction infant prior to administration, inspect solution to verify complete mixing of the suspension. Administer via side port on the special ETT adapter without interrupting mechanical ventilation. Administer the dose in two 2.5 ml/ kg aliquots. Each half-dose is instilled slowly over 1-2 min in small bursts with each inspiration. After the first 2.5 ml/ kg dose turn the infants head and torso 45 degree right for 30 seconds, then return to the midline position and administer the second dose as above. Following the second dose, turn the infants head and torso 45 degree to the left for 30 seconds and return the infant to the midline position
Precautions
Preterm birth, see literature.
Side Effects
Rarely, pulmonary haemorrhage.