Composition
Drop 60 mg: Per 5 ml: Paracetamol 60 mg. Drop 80/100 mg: Per ml: Paracetamol 80/100 mg. Elixir/Liqd/Susp 120 mg/150 mg/160 mg: Per 5 ml: Paracetamol 120 mg/150 mg/160 mg. Elixir/Liqd/Susp 25
Indications & Dosage
Mild to moderate pain, Pyrexia: ORAL: Adult: 0.5-1 g every 4-6 hours; max. 4 g per day. BY IV INF: Adult (body-weight up to 50 kg): 15 mg/kg every 4-6 hours, dose to be administered over 15 minutes; max. 60 mg/kg per day; (body-weight 50 kg and above): 1 gm every 4-6 hours, dose to be administered over 15 minutes; max. 4 g per day. BY RECTUM: Adult: 0.5-1 g every 4-6 hours; max. 4 gm per day. Mild to moderate pain in patients with risk factors for hepatotoxicity, Pyrexia in patients with risk factors for hepatotoxicity: BY IV INF: Adult (body-weight up to 50 kg): 15 mg/kg every 4-6 hours, dose to be administered over 15 minutes; max. 60 mg/kg per day; (body-weight 50 kg and above): 1 gm every 4-6 hours, dose to be administered over 15 minutes; max. 3 g per day. Pain, Pyrexia with discomfort: ORAL: Children 3-5 months: 60 mg every 4-6 hours; 6 months-1 yr: 120 mg every 4-6 hours; 2-3 yrs: 180 mg every 4-6 hours; 4-5 yrs: 240 mg every 4-6 hours; 6-7 yrs: 240-250 mg every 4-6 hours; 8-9 yrs: 360-375 mg every 4-6 hours; max. 4 doses per day;10-11 yrs: 480-500 mg every 4-6 hours; 12-15 yrs: 480-750 mg every 4-6 hours; 16-17 yrs: 0.5-1 g every 4-6 hours. max. 4 doses per day. BY RECTUM: Children 3-11 months: 60-125 mg every 4-6 hours as required; max. 4 doses per day; 1-4 yrs: 125-250 mg every 4-6 hours as required; max. 4 doses per day; 5-11 yrs: 250-500 mg every 4-6 hours as required; max. 4 doses per day; 12-17 yrs: 500 mg every 4-6 hours BY IV INF: Neonate: 10 mg/kg every 4-6 hr, max 30 mg/ kg/day; child body-weight below 10 kg: 10 mg/kg every 4-6 hr, max 30 mg/kg/day; child body-weight 10-50 kg: 15 mg/kg every 4-6 hr, max 60 mg/kg/day; child body-weight over 50 kg: 1 gm every 4-6 hr, max 4 gm daily. Post-immunization pyrexia in infants: ORAL: Child 2-3 months: 60 mg for 1 dose, then 60 mg after 4-6 hours if required; 4 months: 60 mg for 1 dose, then 60 mg after 4-6 hours; max. 4 doses per day. Postoperative pain: Adult: 1 gm every 4-6 hr, max 4 doses/ day Children 1-3 months: 30 mg/kg as a single dose then 15-20 mg/kg every 4-6 hr, max 75 mg/kg/day in divided doses; 3 months-6 yr: 30-40 mg/kg as a single dose then 15-20 mg/kg every 4-6 hr, max 75 mg/kg daily in divided doses; 6-12 yr: 30-40 mg/kg, (max 1 gm) as a single dose then 15-20 mg/kg every 4-6 hr, max 75 mg/kg (max 4 g) daily in divided doses; 12-18 yr: 1 gm every 4-6 hr, max 4 doses/ day.
Administration
IV infusion over 15 min. Store intact vial at room temperature 20C. Do not refrigerate or freeze. Use within 6 hours of opening vial or transferring to another container.
Precautions
Impaired hepatic function, body-weight under 50 kg, chronic alcohol consumption, chronic dehydration, chronic malnutrition, hepatocellular insufficiency, long-term use (especially in those who are malnourished). Before administering, check when paracetamollast administered and cumulative paracetamol dose over previous 24 hours,
Interactions
Drugs which delay gastric emptying (e.g. antichol inergics, narcotics).
Pregnancy
No evidence of risk
Lactation
Caution advised
Side Effects
Rare: Skin reactions, blood disorders, hepatoxicity (high dose), Stevens-Johnson syndrome, toxicepidermal necrolysis, acute generalized exanthematous pustulosis, malaise, leucopenia, neutropenia, thrombocytopenia. With intravenous use: Rare: Flushing, tachycardia, hypotension