Composition
Tab 10 mg/20 mg: Nicorandil 10 mg/20 mg.
Indications & Dosage
Prophylaxis and treatment of stable angina (second-line therapy): Adult: Initially 5-10 mg twice daily, then increased if tolerated to 40 mg twice daily; usual dose 10-20 mg twice daily, use lower initial dose regimen if patient susceptible to headache. Children: Not recommended.
Contraindications
Acute pulmonary oedema, cardiogenic shock, hypovolaemia, left ventricular failure with low filling pressures, severe hypotension
Precautions
Acute myocardial infarction with acute left ventricular failure and low filling pressures, diverticular disease (risk of fistula formation or bowel perforation), G6PD deficiency, heart failure (class III-IV), hyperkalaemia, low systolic blood pressure
Interactions
Hypotensive agents, TCADs.
Pregnancy
Caution advised
Side Effects
Cutaneous vasodilation with flushing, dizziness, headache (especially on initiation), increase in heart rate (at high doses), nausea, rectal bleeding, vomiting, weakness, angioedema, hypotension, myalgia, oralulceration. Rare: Abdominal pain, anal ulceration, cholestasis, GI ulceration, GI haemorrhage, hepatitis, jaundice, pruritus, rash, skin ulceration