FLUSTAL
AMOXICILLIN AND FLUCLOXACLILIN · by STALLION
Composition
Cap 500 mg: Amoxicillin 250 mg, flucloxacillin 250 mg. Inj: 500 mg: Amoxicillin 250 mg, flucloxacillin 250 mg; powder in vial. Susp: 250 mg: Per 5 ml: Amoxicillin 125 mg, flucloxacillin125 mg
Indications & Dosage
Mixed-infections involving beta-lactamase-pro-ducing staphylococci: ORAL: Adults: 500 mg (Amoxicillin 250 mg & flucloxacillin 250 mg) every 6 hr, dose doubled in severe infections. Children above 10 yr: adult dose; below 10 yr: half adult dose, the dose doubled in severe cases. BY IV OR IM INJ: Adults: 500 mg (Amoxicillin 250 mg & flucloxacillin 250 mg) every 6 hr, dose doubled in severe infections. Children 2-10 yrs: half adult dose, the dose doubled in severe cases.
Administration
Administer via slow IV/IM inj.
Contraindications
History of flucloxacillin associated jaundice/hepatic dysfunction, hypersensitivity to penicillins, cephalosporins or other beta-lactams.
Precautions
Renal impairment, acute or chronic lymphocytic leukaemia and cytomegalovirus infection (increased risk of erythematous rashes), glandular fever, maintainadequate hydration with high doses (particularly duringparenteral therapy). Accumulation of sodium can occur with high parenteral IV doses, risk of crystalluria with high doses. Monitor renal, hepatic and haematological function in neonates.
Interactions
Anticoagulants, allopurinol, probenecid.
Pregnancy
Not known to be harmful
Lactation
Not known to be harmful
Side Effects
Hypersensitivity reaction, GI disturbance, nausea and vomiting. Rare: Hepatitis, cholestatic jaundice, haematological and CNS effects, pseudomembranous colitis, increased INR, Stevens-Johnsons syndrome, toxic epidermal necrosis.