FRISIUM
CLOBAZAM · by SANOFI-AVENTIS
Composition
Tab 10 mg: Clobazam 10 mg.
Indications & Dosage
Anxiety (short-term use): Adult: 20-30 mg daily in divided doses, alternatively 20-30 mg once daily, dose to be taken at bedtime; increased if necessary up to 60 mg daily in divided doses, dose only increased in severe anxiety, for debilitated patients, use elderlydose Elderly: 10-20 mg daily. Adjunct in epilepsy: Adult: 20-30 mg daily, then increased if necessary upto 60 mg daily. Children 6-17 yrs: Initially 5 mg daily, dose to be increased if necessary at intervals of 5 days, maintenance 0.3-1 mg/kg daily, daily doses of up to 30 mg may be given as a single dose at bedtime, higher doses should be divided; max. 60 mg per day.
Contraindications
Chronic psychosis, obsessional states, phobic states, respiratory depression, hyperkinesis, severe hepatic impairment. Not recommended for use alone to treat anxiety associated with depression
Precautions
Acute respiratory insufficiency, muscle weakness, organic brain changes, renal and hepatic impairment, personality disorder (dependent,avoidant, obsessive-compulsive) may increase risk ofdependence
Pregnancy
Contraindicated
Lactation
Contraindicated
Side Effects
Amnesia, ataxia, headache, confusion, dependence, drowsiness, lightheadedness, muscle weakness, paradoxical increase in aggression, changes in libido, dizziness, dysarthria, GI disturbances, gynaecomastia, hypotension, incontinence, salivation changes, slurred speech, tremor, urinary retention, vertigo, visual disturbances. Rare: Apnoea, blood disorders, respiratory depression, skin reactions