FUZO SR
ALFUZOSIN · by SHROOQ
Composition
Tab 2.5 mg: Alfuzosin 2.5 mg. Tab 5 mg/10 mg: Alfuzosin 5 mg/10 mg; sustained release tab. XL/Retard Tab 10 mg: Alfuzosin 10 mg.
Indications & Dosage
Benign prostatic hyperplasia: Adult: 10 mg once daily, Elderly: 5 mg morning and evening. Children: Not recommended. Acute urinary retention associated with benign prostatic hyperplasia: Elderly: 10 mg once daily for 2-3 days during catheterisation and for one day after removal; max. 4 days.
Contraindications
History of orthostatic hypotension, avoid if history micturition syncope
Precautions
First dose may cause collapse due to hypotensive effect (therefore should be taken on retiring to bed). Patients should be warned to lie down if symptoms such as dizziness, fatigue or sweating develop, and to remain lying down until they abate completely. Use with caution in hypertension; monitor BP regularly, particularly at start of treatment. Coronary insufficiency; discontinue if angina deteriorates. Withdraw 24 hours before anaesthesia, acute heart failure, history of QT-interval prolongation, patients undergoing cataract surgery (risk of intra-operative floppy iris syndrome), renal and hepatic impairment (reduce dose)
Interactions
Other alpha-blockers, antihypertensives, calcium antagonists
Pregnancy
No evidence of risk in humans
Lactation
Contraindicated, avoid
Side Effects
Angioedema, asthenia, blurred vision, cholestasis, depression, dizziness, drowsiness, dry mouth, erectile disorders (including priapism),GI disturbances, headache, hypersensitivity, hypotension, intra-operative floppy iris syndrome, liver damage, oedema, palpitations, pruritus, rash, rhinitis, syncope, tachycardia, hot flushes, chest pain