GLIMIN
GLICLAZIDE AND METFORMIN · by NOVAMED
Composition
Tab 80/500 mg: Gliclazide 80 mg, metformin HCI 500 mg. Tab 160/500 mg:Gliclazide 160 mg, metformin HCI 500 mg.
Indications & Dosage
Type 2 diabetes when monotherapy results in inadequate glycaemic control: Adults: Usual initial dosage is 80 mg gliclazide and 500 mg metformin. Subsequently the adjustments are done on the basis of glucose blood level achieved. CHILDREN: Not recommended.
Contraindications
Insulin-dependent diabetes, diabetic ketoacidosis, pre-coma and coma, severe renal or hepatic insufficiency, diabetic ketoacidosis, cardiac or respiratory failure, recent MI, administration of iodinated contrast materials. Discontinue for 48 hours before and after elective surgery.
Precautions
Risk of lactic acidosis; discontinue immediately if metabolic acidosis suspected. Monitor renal function at least annually.
Interactions
Miconazole, phenylbutazone, alcohol, insulin, acarbose, biguanides, beta-blockers, fluconazole, ACE inhibitors, H2 receptor antagonists, MAOIs, sulphonamides, NSAIDs, danazol , chlorpromazine, glucocorticoids, ritodrine, salbutamol, terbutaline, anticoagulants, iodinated contrast agents, diuretics, corticosteroids, ACE inhibitors, cimetidine.
Pregnancy
Contraindicated in pregnancy.
Lactation
Contraindicated or not recommended.
Side Effects
Hypoglycaemia, GI disturbances, taste disturbance, rarely lactic acidosis, abnormal liver function tests, hepatitis, skin reactions, reduced B12 absorptions.