GRANDAXIN
TOFISOPAM · by MEDIMPEX
Composition
Tab 50 mg: Tofisopam 50 mg.
Indications & Dosage
Short-term use in anxiety: Adult: 50 mg three times daily; increased up to 300 mg daily; for debilitated and elderly patients, use reduced dose.
Contraindications
Acute pulmonary insufficiencies, CNS depression, respiratory depression, sleep apnoea, phobic or obsessional state, chronic psychosis, unstable myasthenia gravis, severe hepatic impairment. Not recommended for use to treat depression or anxiety associated with depression.
Precautions
Chronic pulmonary insufficiency, renal impairment, mild to moderate hepatic impairment, hypoalbuminaemia, muscle weakness, organic brain changes, personality disorder (dependent, avoidant, obsessive-compulsive), may increase risk of dependence, history of drug or alcohol abuse, elderly. Avoid long term use. Withdraw gradually.
Interactions
: Alcohol, CNS depressants, anticonvulsants, CYP3A4 inhibitors or inducers (e.g. cimetidine, rifampicin).
Pregnancy
Contraindicated
Lactation
Contraindicated
Side Effects
Amnesia, ataxia (especially in the elderly),confusion, dependence, drowsiness, lightheadedness, muscle weakness, paradoxical increase in aggression, dizziness, dysarthria, GI disturbances, gynaecomastia, headache, hypotension, incontinence, salivation changes, slurred speech, tremor, urinary retention, vertigo, visual disturbances. Rare: Apnoea, blood disorders, respiratory depression, jaundice, skin reactions