Composition
Tab: Cyclizine HCI 50 mg. Inj: Cyclizine HCI 50 mg. Syp: Per 5 ml: Cyclizine HCI 12.5 mg.
Indications & Dosage
Nausea, Vomiting, Vertigo, Motion sickness, Labyrinthine Disorders: ORAL: Adult: 50 mg up to 3 times a day, for motion sickness, take 1-2 hrs before departure. BY IV OR IM INJ: Adult: 50 mg 3 times a day Nausea and vomiting of known cause, Nausea and vomiting associated with vestibular disorders and palliative care: ORAL, BY IV OR IM INJ: Children 6-11 yrs: 25 mg up to 3 times a day, IV injection, to be given over 3-5 min, for motion sickness, take 1-2 hrs before departure; 12-17 yrs: 50 mg up to 3 times a day, IV injection, to be given over 3-5 min, for motion sickness, take 1-2 hrs before departure. BY IV INF, OR BY SC INF: Children 1-23 months: 3 mg/kg, dose to be given over 24 hrs; 2-5 years: 50 mg, dose to be given over 24 hrs; 6-11 years: 75 mg, dose to be given over 24 hrs; 12-17 years: 150 mg, dose to be given over 24 hrs. Nausea and vomiting associated with palliative care: BY SC INF: Adult: 150 mg, dose to be given over 24 hours ORAL: Adult: 50 mg up to 3 times a day.
Contraindications
Porphyria, severe hepatic and renal impairment.
Precautions
Epilepsy, glaucoma, may counteract haemodynamic benefits of opioids, neuromuscular disorders-increased risk of transient paralysis with intravenous use, prostatic hypertrophy, pyloroduodenal obstruction, may cause fall in cardiac output and associated increase in heart rate, mean arterial pressure and pulmonary wedge pressure, urinary retention.
Interactions
Anticholinergics, alcohol, CNS disturbances, pethidine.
Pregnancy
Contraindicated
Lactation
Caution advised
Side Effects
Tardive dyskinesia, neurologic effects, neuroleptic malignant syndrome (discontinue )anaphylaxis , angioedema, angle-closure glaucoma, tachycardia, urticaria, arrhythmias,blood disorders, bronchospasm, confusion, convulsions, depression, drowsiness, dizziness, extra pyramidal effects, hypersensitivity reactions, hypotension, liver dysfunction, palpitation, paradoxical stimulation, blur vision, photosensitivity reactions, rashes, sleep disturbances, tremor.