HEPLED
SOFOSBUVIR AND LEDIPASVIR · by CRYSTOLITE
Composition
Each film-coated tablet Contains: Sofosbuvir 400mg and Ledipasvir 90 mg
Indications & Dosage
Chronic hepatitis C of genotypes 1, 4, 5 or 6 in patients with or without compensated cirrhosis or in post-liver transplant (with or without ribavirin), In combination with ribavirin for chronic hepatitis C infection of genotype 3 in patients with compensated cirrhosis or prior treatment failure: Adult: 1 tablet once daily consult product literature for the duration of treatment.
Precautions
Decompensated cirrhosis, patients awaiting liver transplantation, Co-infection with HBV, renal impairment.
Interactions
Femotidine, omeprazole, digoxin, carbamazepine, phenytoin, oxcarbazepine, rifabutin, rifampin, rifapentine, elvitegravir, cobicistat, emtricitabine, tenofovir disoproxil fumarate, tipranavir/ritonavir, St. Johns wart, pravastatin, dabigatran etexilate
Pregnancy
Avoid
Lactation
Avoid
Side Effects
Headache, alopecia, fatigue, anxiety, asthenia, constipation, decreased appetite, depression, diarrhoea, dizziness, dry mouth, dyspnea, gastro-oesophageal reflux, abdominal discomfort, irritability, myalgia, nausea, rash, vomiting, weight loss