Composition
Tab 2 mg/5 mg: Trihexyphenidyl 2 mg/5 mg.
Indications & Dosage
Parkinsonism, Drug-induced extrapyramidal symptoms (but not tardive dyskinesia): Adult: 1 mg daily, then increased in steps of 2 mg every 3-5 days, adjusted according to response; maintenance 5-15 mg daily in 3-4 divided doses; max.20 mg per day Elderly: Lower end of range preferable, not recommended for use in Parkinsons disease because of toxicity in the elderly and the risk of aggravating dementia. Parkinsons disease (in combination with cocareldopa or co-beneldopa): Adult: Maintenance 2-6 mg daily in divided doses, usenot recommended because of toxicity in the elderly andthe risk of aggravating dementia.
Contraindications
GI obstruction, myasthenia gravis
Precautions
Cardiovascular disease, psychotic disorders, pyrexia, those susceptible to angle-closure glaucoma, elderly, hypertension, liable to abuse,prostatic hypertrophy, hepatic or renal disorders. Withdraw treatment slowly.
Interactions
Phenothiazines, antihistamines and antidepres-sants.
Pregnancy
Caution advised
Lactation
Caution advised
Side Effects
Anxiety, blurred vision, confusion, constipation, dizziness, dry mouth, euphoria, hallucinations, impaired memory, nausea, rash, restlessness, tachycardia, urinary retention, vomiting. Rare: Angle-closure glaucoma