Composition
Syp: Per 5 ml: Chlorpheniramine maleate 2 mg. Tab: Chlorpheniramine maleate 4 mg. Inj: Per ml: Chlorpheniramine maleate 10 mg.
Indications & Dosage
Symptomatic relief of allergy such as hay fever, urticaria, food allergy, drug reactions, Relief of itch associated with chicken pox: Adult & Children above 12 yrs: 4 mg every 4-6 hours; max. 24 mg per day. Elderly: 4 mg every 4-6 hours; max. 12 mg per day. Children 1-23 months: 1 mg twice daily; 2-5 years: 1 mg every 4-6 hours; max. 6 mg per day; 6-11 years: 2 mg every 4-6 hours; max.12 mg per day. BY IM INJ, OR BY IV INJ: Adult & Children above 12 yrs: 10 mg, repeated if necessary; max. 4 dosesper day. Children 1-5 months: 250 mcg/kg (max. per dose 2.5 mg), repeated if necessary; max. 4 doses per day; 6 months-5 yrs: 2.5 mg, repeated if necessary;max. 4 doses per day; 6-11 yrs: 5 mg, repeated if necessary; max.4 doses per day. Emergency treatment of anaphylactic reactions: BY IM INJ, OR BY IV INJ: Adult & Children above 12 yrs: 10 mg, repeated if necessary; max. 4 dosesper day. Children 1-5 months: 250 mcg/kg (max. per dose 2.5 mg), repeated if necessary; max. 4 doses per day; 6 months-5 yrs: 2.5 mg, repeated if necessary; max. 4 doses per day; 6-11 yrs: 5 mg, repeated if necessary; max.4 doses per day.
Administration
Chlorpheniramine 10 mg/ml may be administered by SC, IM or IV injection slowly over a period of one min.
Stability
Stored below 25 degree centigrade and protected from light.
Contraindications
Avoid in acute porphyrias, severe liver disease; risk of coma
Precautions
Renal insufficiency, epilepsy, prostatic hypertrophy, pyloroduodenal obstruction, susceptibility to angleclosure glaucoma, urinary retention
Interactions
Alcohol, CNS depressants, MAOls.
Pregnancy
Caution advised, avoid
Lactation
Caution advised, avoid
Side Effects
Headache, drowsiness, dizziness, blurred vision, dry mouth, GI disturbances, psychomotor impairment, urinary retention. Rare: Anaphylaxis, angioedema, angle-closure glaucoma