HYOSCINE
HYOSCINE BUTYLBROMIDE · by INDUS PHARMA
Composition
In: Per ml: Hyoscine-N-butylbromide 20 mg; solution; amp. Syp: Per 5 ml: Hyoscine-N-butylbromide 5 mg. Tab: Hyoscine-N-butylbromide 10 mg. Transdermal Patch: Per patch: Hyoscine 1.5 mg.
Indications & Dosage
Symptomatic relief of gastro-intestinal or genitourinary disorders characterized by smooth muscle spasm: Adults Children above 12 yrs: 20 mg 4 times a day Children 6-11 yrs: 10 mg 3 times a day Irritable bowel syndrome: Adult: 10 mg 3 times a day; increased if necessary up to 20 mg 4 times a day Acute spasm, spasm in diagnostic procedures: BY IM INJ, OR BY SLOW IV INJ: Adult: 20 mg, then after 30 minutes 20 mg again if required, dose may be repeated more frequently in endoscopy; max. 100 mg per day Excessive respiratory secretions in palliative care: ORAL: Children 1 month-1 yr: 300-500 mcg/kg 3-4 times a day (max. per dose 5 mg); 2-4 yrs: 5 mg 3-4 times a day; 5-11 yrs: 10 mg 3-4 times a day; 12-17 yrs: 10-20 mg 3-4 times a day BY IM INJ, OR BY IV INJ: Children 1 month-4 yrs: 300-500 mcg/kg 3-4 times a day (max. per dose 5 mg) 5-11 yrs: 5-10 mg 3-4 times a day 12-17 yrs: 10-20 mg 3-4 times a day BY SC INJ: Adult: 20 mg every 4 hours if required, adjusted according to response to up to 20 mg every 1hour. BY SC INF: Adult: 20-120 mg/24 hours Bowel colic (in palliative care): ORAL: Children 1 month-1 yr: 300-500 mcg/kg 3-4 times a day (max. per dose 5 mg) 2-4 yrs: 5 mg 3-4 times a day 5-11 yrs: 10 mg 3-4 times a day 12-17 yrs: 10-20 mg 3-4 times a day BY IM INJ, OR BY IV INJ: Children 1 month-4 yrs: 300-500 mcg/kg 3-4 times a day (max. per dose 5 mg) 5-11 yrs: 5-10 mg 3-4 times a day 12-17 yrs: 10-20 mg 3-4 times a day BY SC INJ: Adult: 20 mg every 4 hours if required, adjusted according to response to up to 20 mg every 1hour. BY SC INF: Adult: 60-300 mg/24 hours Transdermal Patch: For Motion sickness: Adults: 1 patch on hairless area of skin behind ear 5-6 hr before journey. If necessary, replace with new patch behind other ear after 72 hr. Children above 10 yrs: Same as adults. Below 10 yr: Not recommended.
Stability
Store at 15C-80C (59F-86F). Protect from light.
Contraindications
Myasthenia gravis (but may be used to decrease muscarinic side-effects of anticholinesterases), paralytic ileus, pyloric stenosis, toxic megacolon, and prostatic enlargement.
Precautions
Downs syndrome, in children and in the elderly, gastro-esophageal reflux disease, diarrhoea, ulcerative colitis, autonomic, neuropathy, acute myocardial infarction, hypertension, conditions characterized by tachycardia (including hyperthyroidism, cardiac insufficiency, cardiac surgery), pyrexia, and in individuals susceptible to angle-closure glaucoma.
Interactions
Amantadine, atenolol, digoxin, phenothiazines, tricyclic antidepressants.
Pregnancy
Contraindicated
Lactation
Caution advised
Side Effects
Transient bradycardia (followed by tachycardia, palpitation and arrhythmias), reduced bronchial secretions, urinary urgency and retention, dilatation of the pupils with loss of accommodation, photo-phobia, dry mouth, flushing and dryness of the skin. Side-effects that occur occasionally include confusion (particularly in the elderly), constipation, nausea, vomiting, and giddiness. Very rare! , angle-closure glaucoma may occur.