Composition
Inj: Per vial: Rho (D) immune globulin (Human) equiv to 50 mcg and 300 mcg; Inj: Lyophilized incomplete anti-D sera with negative 1 gm-Anti-D at least 300 mcg Inj: Per 2 ml vial: Immunog
Indications & Dosage
To rhesus-negative woman for prevention of Rh0 (D) sensitisation, following birth of rhesus-positive infant, OR following any potentially sensitizing episode (e.g. stillbirth, abortion, amniocentesis) 20-28 weeks gestation: BY DEEP IM INJ: Females of childbearing potential: 1 vial to be administered immediately or within 72 hours of childbirth; for transplacental bleed of over 4ml fetal red cells, extra100-125 units per ml fetal red cells, subcutaneous route used for patients with bleeding disorders. BY IV INJ: Lyophilized incomplete anti-D sera with negative 1 gm-Anti-D at least 300 mcg: Females: within 84 hr of every termination of pregnancy, abortion or delivery to Rh-negative women with Rh-positive baby. The adjustment of dose can be made as 1 amp of Anti Rh0 300 for every 30-50 ml, transfused blood. For Rh-negative female infant of Rh-positive mothers, one third of adult dose just after delivery. To rhesus-negative woman for prevention of Rh0 (D) sensitisation, antenatal prophylaxis: BY DEEP IM INJ: Females of childbearing potential: 1vial to begiven at weeks 28 and 34 of pregnancy, if infant rhesus-positive, a further dose is still needed immediately or within 72 hours of delivery, subcutaneous route used for patients with bleeding disorders.
Contraindications
Treatment of idiopathic thrombocytopenia purpura in rhesus negative patients, treatment of idiopathic thrombocytopenia purpura in splenectomised patients
Precautions
Immunoglobulin A deficiency, possible interference with live virus vaccines. Should be given with caution with a history of prior systemic allergic reactions following the administration of human im-munoglobulin preparations; physician must weigh the benefits of immunization against the potential risks of hypersensitivity reaction
Interactions
May interfere with the live vaccines to induce an immune response and a suitable interval shduld separate their administration.
Side Effects
Anaphylaxis, abdominal pain, arthralgia, asthenia, back pain, diarrhoea, dizziness, drowsiness, fever, headache, hypertension, hypotension, injection site pain,malaise, myalgia, nausea, pruritus, rash, sweating, vomiting, dyspnea, hypotension, tachycardia, urticaria