Composition
Tab 10 mg/25 mg/75 mg: Imipramine HCI 10 mg/25 mg/75 mg.
Indications & Dosage
Depressive illness: Adult: Initially up to 75 mg daily in divided doses, then increased to 150-200 mg daily, up to 150mg may be given as a single dose at bedtime, dose to be increased gradually; up to 300 mg in hospital patients. Elderly: Initially 10 mg daily, increased to 30-50 mg daily, dose to be increased gradually. Nocturnal enuresis: Child 6-7 years: 25 mg once daily at bedtime, initial period of treatment (including gradual withdrawal) 3 months; full physical examination before further course; 8-10 years: 25-50 mg once daily at bedtime, initial period of treatment (including gradual withdrawal) 3 months-full physical examination before further course; 11-17 years: 50-75 mg once daily at bedtime, initial period of treatment (including gradual withdrawal) 3 months-full physical examination before further course.
Contraindications
Acute porphyrias, arrhythmia, immediate recovery period after myocardial infarction, during the manic phase of bipolar disorder, heart block
Precautions
Cardiovascular disease, diabetes, epilepsy, chronic constipation, history of bipolar disorder, history of mania and psychosis, hyperthyroidism, prostatic hypertrophy, increased intra-ocular pressure, patients with a significant risk of suicide, phaeochromocytoma, susceptibility to angle-closure glaucoma, urinary retention, hepatic impairment (contraindicated if severe),concurrent ECT. Withdraw gradually
Interactions
17 days of MAOls. Other antidepressants, St. Johns Wort, tramadol, drugs that prolong the QT interval (e.g. anti-arrhythmics), moxifloxacin, anticonvulsants, diltiazem, verapamil, clonidine, other antihypertensives, antipsychotics, sotalol, dopaminer??????Calibri�Į�̠�̢۪��_�_�Į�̢���??????SimSun?
Pregnancy
Avoid unless potential benefit outweighs risk
Lactation
Contraindicated, avoid
Side Effects
Agitation, alopecia, anorexia, anxiety, arrhythmia, blurred vision, fatigue, flushing, headache, palpitation, restlessness, chills, confusion, convulsions, delusions, dizziness, drowsiness, dry mouth, dysarthria, ECG changes, galactorrhoea, gynaecomastia, haematologial reactions, hallucinations, headache, heart block, hepatic reactions, hypomania, hyponatraemia, increased appetite, insomnia, irritability, mania, movement disorders, myalgia, nausea, paraesthesia, photosensitivity, postural hypotension, pruritus,rash, sexual dysfunction, sleep disturbances, sudden death, suicidal behavior, sweating, tachycardia, taste disturbance, tinnitus, tremor, urinary retention, urticaria, vomiting, weight changes. Rare: Extrapyramidal symptoms, paralytic ileus